ABSTRACT
Appendicitis is one of the most common surgical emergencies. In spite of the relatively high rate of negative appendectomy, as a result of miss diagnosis, uncertainty of diagnosis still continues to challenge physicians. The objective of this prospective study was to investigate the role of [99m]Tc-Ubiquicidin [UBI] scintigraphy in the diagnosis of acute appendicitis and to compare [99m]Tc-UBI scintigraphy with [99m]Tc-IgG scintigraphy. Twelve patients with right lower quadrant pain and suspicious of acute appendicitis were referred to the nuclear medicine imaging center. Radionuclide imaging was performed with [99m]Tc-UBI in 8 and [99m]Tc-IgG in 4 patients. Ultrasonography, Alvarado scoring and histopathological examinations were also performed as additional diagnostic tests. Reports from [99m]Tc-IgG and [99m]Tc-UBI scintigraphies of all patients were negative. This study may conclude that [99m]Tc-IgG scintigraphy and [99m]Tc-UBI scintigraphy in the detection of appendicitis do not have adequate efficacy. However, in order to better evaluate [99m]Tc-IgG and [99m]Tc-UBI scintigraphy, a comprehensive study on a large number of patients with clinical suspicious of acute appendicitis would be more helpful
ABSTRACT
In this report, the preliminary results of the experimental evaluation of the Performance of HiReSPECT scanner have been illustrated. In order to assess the capability of the scanner in both planar and tomographic modes, three rats were injected with 99mTc, 99mTc-DMSA, and 99mTc-MDP for thyroid scan, kidney scan and bone scan respectively in order to perform planar imaging. In addition, two rats were injected with 99mTc-MIBI and 99mTc-DMSA to perform cardiac and kidney tomographic imaging, respectively. Tomographic and planar scans of the rat organs showed that radioactive distribution in cardiac, kidney, bone and thyroid images exhibited detailed physiologic information of the imaged organs. Due to high resolution performance of the scanner, thyroid lobes are well depicted and distinguished from each other. Results of the evaluation of the planar and tomographic images indicated that HiReSPECT has appropriate imaging capability as an imaging system in biomedical research
ABSTRACT
The aim of present study was to estimate effective dose from most common procedures performed in nuclear medicine departments of Golestan province. Data of nuclear medicine procedures performed in 2 nuclear medicine departments in Golestan province were collected during 4 years. Effective dose, collective effective dose and effective dose per examination were calculated using standard dosimetry tables. Based on the data of this study, results of 10437 nuclear medicine procedures performed during 4 years have lead to 3.97 mSv as average effective dose per examination and 10.37 human-Sv as mean collective effective dose. It was also revealed that Tc-99m was the main source of effective dose [98.3%], bone scan was the most common procedure [25.9%] and cardiac scan [MIBI-rest] has the highest collective effective dose [33.5%] during 4 years. Beside the cardiac scan which was the most common nuclear medicine procedure and the main contributor of effective dose in patients, due to geographical condition of the northeast of Iran, bone scan was the highest performed nuclear medicine examination in the Golestan province
Subject(s)
Radiation DosageABSTRACT
To assess relative biological effectiveness [RBE] of [131]I radiation relative to [60]Co gamma rays in glioblastoma spheroid cells. In this experimental study, glioblastoma spheroid cells were exposed to [131]I radiation and [60]Co gamma rays. Radiation induced DNA damage was evaluated by alkaline comet assay. Samples of spheroid cells were treated by radiation from [131]I for four different periods of time to find the dose-response equation. Spheroid cells were also exposed by 200 cGy of [60]Co gamma rays as reference radiation to induce DNA damage as endpoint. Resulted RBE of [131]I radiation relative to [60]Co gamma rays in 100 microm giloblastoma spheroid cells was equal to 1.16. The finding of this study suggests that [131]I photons and electrons can be more effective than [60]Co gamma rays to produce DNA damage in glioblastoma spheroid cells